untreated HIV infection will kill 60% of children within two and a half
years, but the equivalent infection in monkeys is not fatal.
The findings could lead to new immune-based therapies for HIV infection.
virus eventually wipes out the immune system, leaving the body
vulnerable to other infections, what is known as acquired human
immunodeficiency syndrome (Aids).
The researchers analysed the
blood of 170 children from South Africa who had HIV, had never had
antiretroviral therapy and yet had not developed Aids.
Tests showed they had tens of thousands of human immunodeficiency viruses in every millilitre of their blood.
would normally send their immune system into overdrive, trying to fight
the infection, or simply make them seriously ill, but neither had
Keep calm and carry on
Philip Goulder, one of the researchers from the University of Oxford,
told the BBC: “Essentially, their immune system is ignoring the virus as
far as possible.
“Waging war against the virus is in most cases the wrong thing to do.”
Counter-intuitively, not attacking the virus seems to save the immune system.
HIV kills white blood cells – the warriors of the immune system.
And when the body’s defences go into overdrive, even more of them can be killed by chronic levels of inflammation.
Goulder said: “One of the things that comes out of this study is that
HIV disease is not so much to do with HIV, but with the immune response
For scientists, the way the 10% of children cope with the
virus has striking similarities to the way more than 40 non-human
primate species cope with simian immunodeficiency virus or SIV.
They have had hundreds of thousands of years to evolve ways to tackle the infection.
selection has worked in these cases, and the mechanism is very similar
to the one in these kids that don’t progress,” Prof Goulder said.
War or peace?
This defence against Aids is almost unique to children.
Adult humans’ immune systems tend to go all-out to finish off the virus in a campaign that nearly always ends in failure.
have a relatively tolerant immune system, which becomes more aggressive
in adulthood – chickenpox, for example, is far more severe in adults
due to the way the immune system reacts.
But this does mean that as the protected children age and their immune system matures, there is a risk of them developing Aids.
Some do, some remain Aids-free.
Ann Chahroudi and Dr Guido Silvestri, from Emory University in the US,
said the study may have found the “very earliest signs of coevolution of
HIV in humans”.
In a commentary, they added: “It is not known
whether it would be clinically safe for these newly identified HIV
infected paediatric non-progressors to remain off-therapy.
assessment is further complicated by the fact that prevention of HIV
transmission to sexual partners becomes relevant in adolescence.”
People with HIV can have normal life-expectancy if they have access to antiretroviral drugs.
their super-heated immune system never returns to normal, and they face
greater risks of cardiovascular disease, cancer and dementia.
Prof Goulder believes these findings in children could ultimately help rebalance the immune system in all HIV patients.
told the BBC: “We may be identifying an entirely new pathway by
studying kids that in the longer term could be translated to new
treatments for all HIV infected people.”